Ultragenyx Reports the First Patient Dosing of Setrusumab (UX143) in P-II/III (Orbit) Study for the Treatment of Osteogenesis Imperfecta
Shots:
- The first patient has been dosed in a P-II/III (Orbit) study that evaluates the effect of setrusumab vs PBO in a ratio (1:1:1) & (2:1) in 36 & 195 patients, respectively aged 5 to <26yrs. with OI. The study is designed to study fracture risk reduction in a younger population
- The study is based on the results from the 12mos. P-IIb (ASTEROID) study showed a clear, dose-dependent & significant effect on bone formation & bone density at multiple anatomical sites
- The therapy is also being evaluated in a P-III study in patients aged 2 to <5yrs. for OI over 12 to 24mos. with an expected initiation in H2’22. The company also plans to continue studying setrusumab in adult patients aged 25yrs. with OI
Ref: Globe Newswire | Image: Ultragenyx
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